Chemistry Organic Building Blocks Bromides 1-bromo-2-chloro-3-fluorobenzene
Ambeed provide 13 derivatives of 1-bromo-2-chloro-3-fluorobenzene.
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—Cl,—F).
Electrophilic Aromatic Substitution (EAS): Bromobenzene can react with electrophiles in substitution reactions, such as nitration, sulfonation, halogenation, and Friedel-Crafts acylation/alkylation.
Reduction: Chlorobenzene can be reduced to form cyclohexane under certain conditions, often using strong reducing agents like sodium in the presence of alcohol.
Fluorine Substitution: Fluorobenzene can undergo further substitution reactions to replace the fluorine atom with other functional groups. This can be achieved through nucleophilic aromatic substitution reactions. The electron-withdrawing nature of fluorine can affect the regioselectivity and reactivity of such substitutions.
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2-(2-Bromo-3-chloro-4-fluorophenyl)acetic acid
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Methyl 6-amino-4-bromo-3-chloro-2-fluorobenzoate
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1-Bromo-2-chloro-3-fluoro-4-iodobenzene
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3-Bromo-4-chloro-5-fluorobenzonitrile
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1,3-Dibromo-2,4-dichloro-5-fluorobenzene
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1-Bromo-2-chloro-3-fluoro-4-(trifluoromethyl)benzene
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1-Bromo-2-chloro-4-ethoxy-3-fluorobenzene