Chemistry Organic Building Blocks Bromides 1-bromo-2-fluoro-3-methoxybenzene
Ambeed provide 7 derivatives of 1-bromo-2-fluoro-3-methoxybenzene.
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—F,—OCH3).
Sonogashira Coupling: Bromobenzene can undergo coupling reactions with terminal alkynes using a palladium catalyst, leading to the formation of substituted alkynes.
Fluorine Substitution: Fluorobenzene can undergo further substitution reactions to replace the fluorine atom with other functional groups. This can be achieved through nucleophilic aromatic substitution reactions. The electron-withdrawing nature of fluorine can affect the regioselectivity and reactivity of such substitutions.
Wacker Oxidation: Methoxybenzene can undergo the Wacker oxidation using palladium chloride and copper chloride to form the corresponding ketone.
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4-Bromo-3-fluoro-2-methoxybenzonitrile
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3-Bromo-2,4-difluoro-1,5-dimethoxybenzene
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4,6-Dibromo-3-fluoro-2-methoxyaniline