Chemistry Organic Building Blocks Bromides 1-bromo-3-chloro-2-methylbenzene
Ambeed provide 6 derivatives of 1-bromo-3-chloro-2-methylbenzene.
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—CH3,—Cl).
Sonogashira Coupling: Bromobenzene can undergo coupling reactions with terminal alkynes using a palladium catalyst, leading to the formation of substituted alkynes.
Alkylation: Similar to acylation, toluene can also undergo Friedel-Crafts alkylation reactions, where an alkyl group is introduced onto the benzene ring. Alkylation reactions also require a Lewis acid catalyst.
Sandmeyer Reaction: Chlorobenzene can be converted to other aryl halides through the Sandmeyer reaction, involving replacement of the chlorine atom with other halogens.
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1-Bromo-3-chloro-4-iodo-2-methylbenzene