Chemistry Organic Building Blocks Bromides 1-bromo-3-fluoro-2-methylbenzene
Ambeed provide 17 derivatives of 1-bromo-3-fluoro-2-methylbenzene.
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—CH3,—F).
Sonogashira Coupling: Bromobenzene can undergo coupling reactions with terminal alkynes using a palladium catalyst, leading to the formation of substituted alkynes.
Sulfonation: Toluene can be sulfonated, leading to the introduction of a sulfonic acid group (-SO3H) onto the benzene ring. This is often carried out using concentrated sulfuric acid.
Cross-Coupling Reactions: Fluorobenzene can be utilized in cross-coupling reactions, such as Suzuki-Miyaura, Negishi, and Stille reactions. These reactions involve coupling a halogenated aromatic compound with an organometallic reagent, resulting in the formation of new carbon-carbon bonds.
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Methyl 3-bromo-5-fluoro-4-methylbenzoate
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2,3-Dibromo-1-chloro-5-fluoro-4-methylbenzene
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4-Bromo-2-fluoro-3-methylbenzonitrile
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Methyl 4-bromo-2-fluoro-3-methylbenzoate