Chemistry Organic Building Blocks Bromides 1-bromo-3-fluoro-2-nitrobenzene
Ambeed provide 9 derivatives of 1-bromo-3-fluoro-2-nitrobenzene.
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—NO2,—F).
Sonogashira Coupling: Bromobenzene can undergo coupling reactions with terminal alkynes using a palladium catalyst, leading to the formation of substituted alkynes.
Reduction: The nitro group in nitrobenzene can be reduced to an amino group (-NH2) using reducing agents like iron and hydrochloric acid, or more commonly, using catalytic hydrogenation. This reaction produces aniline.
Fluorine Substitution: Fluorobenzene can undergo further substitution reactions to replace the fluorine atom with other functional groups. This can be achieved through nucleophilic aromatic substitution reactions. The electron-withdrawing nature of fluorine can affect the regioselectivity and reactivity of such substitutions.
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1-Bromo-5-chloro-3-fluoro-2-nitrobenzene
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Methyl 3-bromo-5-fluoro-4-nitrobenzoate
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Methyl 4-bromo-2,6-difluoro-3-nitrobenzoate
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1,2-Dibromo-4,5-difluoro-3-nitrobenzene