Chemistry
Organic Building Blocks
Bromides
1-bromo-3-methyl-2-nitrobenzene
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—NO2,—CH3).
Sonogashira Coupling: Bromobenzene can undergo coupling reactions with terminal 【alkynes|https://www.ambeed.com/alkynyls.html】 using a palladium catalyst, leading to the formation of substituted 【alkynes|https://www.ambeed.com/alkynyls.html】.
Nitration: Nitrobenzene can undergo nitration reactions, where a nitro group (-NO2) is introduced onto the benzene ring. This is typically achieved by treating nitrobenzene with a mixture of concentrated sulfuric acid and concentrated nitric acid.
Sulfonation: Toluene can be sulfonated, leading to the introduction of a sulfonic acid group (-SO3H) onto the benzene ring. This is often carried out using concentrated sulfuric acid.
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2-Bromo-1-methoxy-4-methyl-3-nitrobenzene
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1-Bromo-4-fluoro-3-methyl-2-nitrobenzene