Chemistry
Organic Building Blocks
Bromides
1-bromo-4-chloro-2-fluorobenzene
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—F,—Cl).
Suzuki-Miyaura Coupling: Bromobenzene can participate in cross-coupling reactions with organoboron compounds in the presence of a palladium catalyst, resulting in the formation of biaryl compounds.
Fluorine Substitution: Fluorobenzene can undergo further substitution reactions to replace the fluorine atom with other functional groups. This can be achieved through nucleophilic aromatic substitution reactions. The electron-withdrawing nature of fluorine can affect the regioselectivity and reactivity of such substitutions.
Grignard Reaction: Chlorobenzene can react with magnesium metal to form phenylmagnesium chloride, which can then react with various electrophiles to introduce new functional groups onto the aromatic ring.
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(5-Bromo-2-chloro-4-fluorophenyl)methanol
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2-(5-Bromo-2-chloro-4-fluorophenyl)acetonitrile