Chemistry Organic Building Blocks Bromides 1-bromo-4-styrylbenzene
Ambeed provide 5 derivatives of 1-bromo-4-styrylbenzene.
These compounds have the same murcko framework: 1-bromo-4-styrylbenzeneNucleophilic Substitution: The bromine atom is a leaving group, and the compound can undergo nucleophilic substitution reactions with nucleophiles, such as amines or hydroxide ions, leading to the replacement of the bromine atom.
Suzuki Coupling: The styryl group can participate in Suzuki coupling reactions, where it reacts with an organoboron compound in the presence of a palladium catalyst to form biaryl compounds.
Heck Coupling: The styryl group can also participate in Heck coupling reactions, where it reacts with an alkene in the presence of a palladium catalyst, typically forming a new carbon-carbon bond.
Bromine Elimination: Under certain conditions, the bromine atom may be eliminated through a dehydrobromination reaction, especially in the presence of a strong base.
Aromatic Bromination: The benzene ring can undergo electrophilic aromatic substitution reactions. However, since one position is already occupied by a bromine atom, further bromination may be less favorable.
Grignard Formation: The compound can react with a Grignard reagent to form a new carbon-carbon bond, especially with the styryl group.
Bromination or Halogen Exchange: The bromine atom can be replaced with another halogen in the presence of a suitable halogenating agent.
Bromine Oxidation: The bromine atom can be oxidized to a carbonyl group under certain conditions.
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