Chemistry
Heterocyclic Building Blocks
Tetrazoles
1-phenyl-1H-tetrazole
Alkylation: It can be alkylated with alkyl halides or alkyl sulfonates to introduce alkyl groups to the tetrazole ring.
Nucleophilic Substitution: The nitrogen atoms in the tetrazole ring can act as nucleophiles in substitution reactions.
Cyclization Reactions: It can participate in cyclization reactions, such as the synthesis of 1,5-disubstituted tetrazoles from α,β-unsaturated nitriles or nitroalkenes.
Azide Reactions: 1-phenyl-1H-tetrazole can react with azides to form triazoles. This reaction is often used in click chemistry.
Oxidation and Reduction: Depending on the reaction conditions, it can be oxidized or reduced to form different products.
Metal-Catalyzed Reactions: Transition metal catalysts can be used to facilitate various reactions involving 1-phenyl-1H-tetrazole, such as C-N coupling reactions.
Condensation Reactions: It can be involved in condensation reactions with carbonyl compounds or other reagents to form heterocyclic compounds.
Substitution Reactions: The phenyl group in 1-phenyl-1H-tetrazole can undergo substitution reactions, depending on the reagents and conditions.
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2-(4-(1H-Tetrazol-1-yl)phenyl)acetic acid
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4-(5-Mercapto-1H-tetrazol-1-yl)benzoic acid
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N-(3-(5-Mercapto-1H-tetrazol-1-yl)phenyl)acetamide