Chemistry
Heterocyclic Building Blocks
Pyrazoles
1-trityl-1H-pyrazole
Substitution Reactions: The trityl group is often used as a protecting group for sensitive functional groups. You can remove the trityl group through acidic conditions (e.g., using an acid like HCl or TFA) to regenerate the free pyrazole.
Alkylation: You can alkylate the nitrogen atoms of the pyrazole ring using alkyl halides or other alkylating agents. This can be useful for introducing various alkyl substituents.
Nucleophilic Substitution: The nitrogen atoms in the pyrazole ring can act as nucleophiles in various reactions. For example, they can react with alkyl halides in nucleophilic substitution reactions.
Cross-Coupling Reactions: You can perform cross-coupling reactions, such as Suzuki-Miyaura or Heck reactions, using appropriate reagents and conditions to attach different groups to the pyrazole ring.
Cyclization: The pyrazole ring itself can participate in cyclization reactions to form fused-ring systems or other heterocycles.
Metalation: You can metalate the pyrazole ring by treating it with metal bases like butyl lithium or Grignard reagents. This can lead to the formation of organometallic complexes.
Condensation Reactions: Pyrazoles can participate in condensation reactions with carbonyl compounds (e.g., ketones and aldehydes) to form pyrazolines or other products.
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Ethyl 1-trityl-1H-pyrazole-4-carboxylate
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(3-(Ethoxycarbonyl)-1-trityl-1H-pyrazol-4-yl)boronic acid