Chemistry Heterocyclic Building Blocks Imidazoles 1H-imidazo[4,5-b]pyridine
Ambeed provide 14 derivatives of 1H-imidazo[4,5-b]pyridine.
These compounds have the same murcko framework: 1H-imidazo[4,5-b]pyridine.
Electrophilic Aromatic Substitution: 1H-imidazo[4,5-b]pyridine can undergo electrophilic aromatic substitution reactions, where it reacts with electrophiles to substitute one of the hydrogen atoms on the aromatic ring. This can lead to the introduction of various functional groups onto the ring.
Nucleophilic Substitution: If there are suitable leaving groups on the molecule, nucleophilic substitution reactions can occur. Nucleophiles can displace the leaving group to form new derivatives.
Alkylation and Acylation: 1H-imidazo[4,5-b]pyridine can react with alkylating agents or acylating agents to introduce alkyl or acyl groups onto the heterocyclic ring.
Reduction: Reduction reactions can be employed to reduce the imidazo[4,5-b]pyridine ring, typically using reducing agents like hydrogen and a catalyst or other reducing agents.
Oxidation: Oxidation reactions can be used to oxidize the compound, introducing oxygen-containing functional groups.
Cyclization: Depending on the reaction conditions and the presence of appropriate functional groups, further cyclization reactions may occur to form more complex ring structures.
Metal-Catalyzed Reactions: Transition metal catalysts can facilitate various reactions, such as cross-coupling reactions or C-H activation reactions, to modify the structure of 1H-imidazo[4,5-b]pyridine.
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5,7-Dichloro-2-methyl-1H-imidazo[4,5-b]pyridine
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5-Methyl-1H-imidazo[4,5-b]pyridine
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5-(Trifluoromethyl)-1H-imidazo[4,5-b]pyridine
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6-Bromo-7-methyl-1H-imidazo[4,5-b]pyridine
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Methyl 1H-imidazo[4,5-b]pyridine-6-carboxylate
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5,7-Dichloro-2-(trifluoromethyl)-1H-imidazo[4,5-b]pyridine