Chemistry
Heterocyclic Building Blocks
Imidazoles
1H-imidazo[4,5-c]pyridine
Electrophilic Aromatic Substitution: The pyridine ring in 1H-imidazo[4,5-c]pyridine can undergo electrophilic aromatic substitution reactions, where it can be substituted by various electrophiles (e.g., halogens, acyl groups, nitro groups) to form substituted derivatives.
Nucleophilic Substitution: The nitrogen atoms in the imidazole ring can act as nucleophiles, reacting with electrophiles. For instance, they can react with alkylating agents to form alkylated derivatives.
Reduction: 1H-imidazo[4,5-c]pyridine can be reduced to form dihydro-1H-imidazo[4,5-c]pyridine by using reducing agents like sodium borohydride.
Oxidation: It can be oxidized to form various oxidation products using strong oxidizing agents such as potassium permanganate or hydrogen peroxide.
Alkylation: The nitrogen atoms in the imidazole ring can be alkylated with alkyl halides or alkylating reagents to introduce alkyl groups at those positions.
Heterocycle Synthesis: 1H-imidazo[4,5-c]pyridine can be used as a starting material for the synthesis of more complex heterocyclic compounds.
Metal-Catalyzed Reactions: Various transition metal-catalyzed reactions can be applied to functionalize the molecule at specific positions.
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6-Chloro-2-methyl-1H-imidazo[4,5-c]pyridine
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4-Chloro-7-fluoro-1H-imidazo[4,5-c]pyridine
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7-Fluoro-1H-imidazo[4,5-c]pyridin-4-amine
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3H-Imidazo[4,5-c]pyridine-4-carboxylic acid
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7-Chloro-2-methylimidazo[4,5-c]pyridine