Chemistry Heterocyclic Building Blocks Indazoles 1H-indazol-4-amine

1H-indazol-4-amine

Ambeed provide 12 derivatives of 1H-indazol-4-amine.

These compounds have the same murcko framework: 1H-indazol-4-amine

Substitution Reactions: The amino group can undergo nucleophilic substitution reactions with various electrophiles, leading to the formation of substituted amines.
Alkylation: The nitrogen atom in the indazole ring can be alkylated by reaction with alkyl halides or sulfonates.
Acylation: The nitrogen atom in the indazole ring can undergo acylation reactions to form N-acyl derivatives.
Reduction: The imine group can be reduced to the corresponding amine using reducing agents such as sodium borohydride or hydrogen gas over a metal catalyst.
Ring-opening Reactions: The indazole ring may undergo ring-opening reactions under certain conditions, leading to the formation of linear or branched compounds.
Condensation Reactions: It can participate in condensation reactions with carbonyl compounds or other nucleophiles to form cyclic compounds or larger molecules.
Protonation: The amine group can be protonated under acidic conditions to form the corresponding ammonium salt.
Dehydration: Under appropriate conditions, dehydration reactions can occur to eliminate water and form unsaturated compounds.

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Conditions to empty

Framework+−

(1H-indazol-4-yl)boronic acid (1H-indazol-6-yl)boronic acid 1-(1H-indazol-1-yl)ethan-1-one 1-(tetrahydro-2H-pyran-2-yl)-1H-indazole 1-benzyl-1H-indazole 1-ethyl-1H-indazole 1H-indazol-3-amine 1H-indazol-3-ol 1H-indazol-4-amine 1H-indazol-4-ol 1H-indazol-5-amine 1H-indazol-6-amine 1H-indazol-6-ol 1H-indazol-7-amine 1H-indazole-3-carbaldehyde 1H-indazole-3-carbonitrile 1H-indazole-3-carboxylic acid 1H-indazole-4-carboxylic acid 1H-indazole-5-carboxylic acid 1H-indazole-7-carboxylic acid 2,3-dimethyl-2H-indazole 2-methyl-2H-indazole 3-(piperidin-4-yl)-1H-indazole 3-chloro-1H-indazole 4,5,6,7-tetrahydro-1H-indazole 4-chloro-1H-indazole 4-fluoro-1H-indazole 4-methoxy-1H-indazole 4-methyl-1H-indazole 4-nitro-1H-indazole 5-bromo-1H-indazole 5-chloro-1H-indazole 5-methoxy-1H-indazole 5-nitro-1H-indazole 6-(trifluoromethyl)-1H-indazole 6-bromo-1H-indazole 6-chloro-1H-indazole 6-fluoro-1H-indazole 6-methoxy-1H-indazole 6-methyl-1H-indazole 6-nitro-1H-indazole 7-bromo-1H-indazole 7-chloro-1H-indazole 7-fluoro-1H-indazole 7-methoxy-1H-indazole 7-nitro-1H-indazole methyl 1H-indazole-3-carboxylate methyl 1H-indazole-4-carboxylate methyl 1H-indazole-5-carboxylate methyl 1H-indazole-6-carboxylate methyl 1H-indazole-7-carboxylate methyl 2-methyl-2H-indazole-3-carboxylate tert-butyl 1H-indazole-1-carboxylate

By Key Group+−

amino-indazole amino-indazole-carboxylate bromo-ethyl-indazole bromo-fluoro-indazole bromo-indazol-amine bromo-indazole bromo-indazole-carboxylate bromo-methoxy-indazole bromo-nitro-indazole bromoindazole-carboxylic-acid bromoisopropyl-indazole bromomethyl-indazole chlorindazole-carboxylic acid chloro-indazole chloro-indazole-amine chloro-indazole-carboxylate chloro-methyl-indazole dimethyl-indazole dioxaborolan-indazole dioxaborolane-indazole-carboxylate fluoro-indazol-amine fluoro-indazole-carboxylate fluoro-indazole-carboxylic acid fluoro-methyl-indazole indazo-piperazine indazol-amide indazol-amine indazol-boronic acid indazol-one Indazole Derivatives indazole-benzene indazole-carbonitrile indazole-carboxylate indazole-carboxylic acid indazole-hydrochloride indazole-hydroxyl indazole-methanol iodo-indazol-amine iodo-indazole iodo-indazole-carboxylate iodomethyl-indazole methoxy-indazole-carboxylate methoxyindazole-carboxylic acid methyl-indazol-amine methyl-indazolamide methyl-indazole-carboxylic-acid methyl-nitro-indazole methylindazole nitro-indazol-amine tetrahydropyran-indazole trifluoromethyl-indazole

By Parent Nucleus+−

Aliphatic Heterocycles Aromatic Heterocycles Imidazoles Other Aliphatic Heterocycles Other Aromatic Heterocycles Piperazines Piperidines Pyrazoles Pyridines Pyrimidines Pyrrolidines Tetrahydropyrans

By Functional Group+−

Alcohols Aldehydes Aliphatic Chain Hydrocarbons Aliphatic Cyclic Hydrocarbons Alkenyls Alkyls Alkynyls Amides Amines Aryls Benzyl bromides Bromides Carboxylic Acids Chiral Building Blocks Chlorides Esters Ethers Fluorinated Building Blocks Iodides Ketones Nitriles Nitroes Organoboron Oximes Phenols Phosphoruses Sulfamides Sulfides Sulfonates Sulfonic Acids Trifluoromethyls

By Chemical Elements+−

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    Formula Weight+−

    cLogP+−

    H-Acceptors+−

    H-Donors+−

    Polar Surface Area+−

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    NNCH/NNH+−

    sp3-Atoms+−

    Non-Aromatic Rings+−

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    Rotatable Bonds+−

    By Configuration+−

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