Chemistry Heterocyclic Building Blocks Pyrazines 1H-pyrazolo[3,4-b]pyrazine
Ambeed provide 5 derivatives of 1H-pyrazolo[3,4-b]pyrazine.
These compounds have the same murcko framework: 1H-pyrazolo[3,4-b]pyrazine.
Arylation or Alkylation: You can introduce substituents at various positions on the pyrazine rings through reactions like Friedel-Crafts acylation or alkylation.
Oxidation: 1H-pyrazolo[3,4-b]pyrazine can be oxidized under certain conditions to produce various oxidized derivatives.
Reduction: Reduction reactions can be performed to reduce the compound to its corresponding dihydro form or even to more reduced derivatives.
Halogenation: You can halogenate the compound using reagents like bromine or chlorine to introduce halogen atoms onto the pyrazine rings.
Condensation Reactions: It can participate in various condensation reactions, such as Mannich reactions, to form more complex molecules.
Metalation: Metal-catalyzed reactions can be employed to introduce metal atoms or groups onto the pyrazine rings.
Cyclization: The compound can undergo intramolecular cyclization reactions to form other fused or bridged heterocycles.
Nucleophilic Substitution: Depending on the reaction conditions, nucleophilic substitution reactions can take place at various positions within the molecule.
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6-Chloro-3-iodo-1H-pyrazolo[3,4-b]pyrazine
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3-Bromo-1H-pyrazolo[3,4-b]pyrazine