Chemistry
Heterocyclic Building Blocks
Pyrazoles
1H-pyrazolo[4,3-d]pyrimidine
Nitrosation: The pyrimidine ring can be nitrosated with nitrous acid to form the corresponding nitroso compound.
Alkylation: 1H-pyrazolo[4,3-d]pyrimidine can undergo alkylation reactions, where alkyl groups are introduced onto the nitrogen atoms or other suitable positions in the molecule.
Amination: Amination reactions can be carried out to introduce amino groups onto the pyrazolo[4,3-d]pyrimidine ring system.
Halogenation: Halogenation reactions, such as bromination or chlorination, can be used to introduce halogen atoms onto the pyrazole or pyrimidine rings.
Reduction: The nitro group, if present, can be reduced to an amino group using reducing agents like hydrogen and a catalyst.
Cyclization: Depending on the reaction conditions and substituents, 1H-pyrazolo[4,3-d]pyrimidine can undergo intramolecular cyclization reactions to form fused heterocyclic compounds.
Oxidation: Oxidation reactions can be employed to convert certain functional groups within the molecule, such as sulfides to sulfoxides or sulfones.
Nucleophilic substitution: If suitable leaving groups are present, nucleophilic substitution reactions can occur at specific positions in the molecule.
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5-Chloro-3-iodo-1H-pyrazolo[4,3-d]pyrimidine
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3-Bromo-5,7-dichloro-1H-pyrazolo[4,3-d]pyrimidine
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3-Bromo-5-chloro-1H-pyrazolo[4,3-d]pyrimidine