Chemistry Organic Building Blocks Benzene Compounds 2,2',3,3'-tetrahydro-1,1'-spirobi[indene]
Ambeed provide 5 derivatives of 2,2',3,3'-tetrahydro-1,1'-spirobi[indene].
These compounds have the same murcko framework: 2,2',3,3'-tetrahydro-1,1'-spirobi[indene].
Oxidation: Spirobi[indene] can undergo oxidation reactions under appropriate conditions. For example, it can be oxidized using strong oxidizing agents such as potassium permanganate (KMnO4) or chromic acid (H2CrO4) to yield various oxidation products.
Reduction: Spirobi[indene] can also be subjected to reduction reactions. Common reducing agents like lithium aluminum hydride (LiAlH4) or hydrogen gas H2 in the presence of a catalyst can be used to reduce the compound to its corresponding dihydrospirobi[indene] or even tetrahydrospirobi[indene].
Halogenation: The compound can undergo halogenation reactions when treated with halogenating agents such as bromine (Br2) or chlorine (Cl2). This can result in the introduction of halogen atoms into the spirobi[indene] structure.
Substitution Reactions: Depending on the reaction conditions, substitution reactions can occur, leading to the replacement of hydrogen atoms with other functional groups or substituents. These reactions can be achieved through the use of appropriate reagents and catalysts.
Cycloaddition Reactions: Spirobi[indene] can participate in cycloaddition reactions, such as Diels-Alder reactions or other pericyclic reactions, depending on the reaction conditions and the nature of the reactants involved.
Functional Group Transformations: Various functional group transformations, such as acylation, alkylation, and esterification, can be performed on spirobi[indene] by treating it with appropriate reagents.
Ring-Opening Reactions: Spirobi[indene] can undergo ring-opening reactions under certain conditions, leading to the cleavage of one or more of its rings.
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(S)-2,2',3,3'-Tetrahydro-1,1'-spirobi[1H-indene]-7,7'-diol
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(R)-2,2',3,3'-Tetrahydro-1,1'-spirobi[indene]-7,7'-diol
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2,2',3,3'-Tetrahydro-1,1'-spirobi[indene]-7,7'-diol
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5,5'-Diamino-3,3,3',3'-tetramethyl-2,2',3,3'-tetrahydro-1,1'-spirobi[indene]-6,6'-diol
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5,5',6,6'-Tetrahydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindane