Chemistry Heterocyclic Building Blocks Pyridines 2,2-dimethyl-1-(pyridin-2-yl-l2-azaneyl)propan-1-one
Ambeed provide 7 derivatives of 2,2-dimethyl-1-(pyridin-2-yl-l2-azaneyl)propan-1-one.
These compounds have the same murcko framework: 2,2-dimethyl-1-(pyridin-2-yl-l2-azaneyl)propan-1-oneNucleophilic Addition: The ketone group could undergo nucleophilic addition reactions with various nucleophiles, such as amines, alcohols, or cyanide ions, depending on the reaction conditions.
Acylation: The pyridine nitrogen could act as a nucleophile in an acylation reaction with the ketone carbonyl group, forming a substituted amide.
Condensation Reactions: The ketone group could undergo condensation reactions with other carbonyl compounds, such as in a Claisen condensation or a Knoevenagel condensation, leading to the formation of β-diketones or unsaturated compounds.
Reduction: The ketone group could be reduced to the corresponding alcohol using reducing agents like sodium borohydride or lithium aluminum hydride.
Oxidation: Under appropriate conditions, the compound could undergo oxidation, converting the ketone group to a carboxylic acid or other oxidized functional groups.
Substitution Reactions: The pyridine ring could undergo substitution reactions at various positions, depending on the reagents and conditions used.
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2,2-Dimethyl-N-pyridin-2-yl-propionamide
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N-(4-(Hydrazinecarbonyl)pyridin-2-yl)pivalamide
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2,2-Dimethyl-N-(6-methylpyridin-2-yl)propanamide
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N-(4-Chloro-3-iodopyridin-2-yl)pivalamide