Chemistry Heterocyclic Building Blocks Pyridines 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
Ambeed provide 13 derivatives of 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole.
These compounds have the same murcko framework: 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole.
Aromatic Electrophilic Substitution: The indole ring can undergo electrophilic aromatic substitution reactions. This can include reactions with electrophiles like nitration, halogenation, sulfonation, and Friedel-Crafts acylation or alkylation.
Reduction: Reduction reactions can be used to convert the compound to the corresponding tetrahydroindole, typically using reducing agents like hydrogen and a metal catalyst.
Oxidation: Oxidation reactions can be used to convert the compound into various oxidized derivatives.
Nucleophilic Substitution: The compound can undergo nucleophilic substitution reactions at suitable positions. This can include reactions with nucleophiles like amines or alkoxides, leading to the formation of new substituted derivatives.
Ring Opening Reactions: Ring opening reactions can be performed to open up the indole ring system, typically through the use of strong nucleophiles or acids.
Cyclization: The compound can undergo intramolecular cyclization reactions to form different cyclic derivatives.
Functional Group Transformations: Various functional group transformations can be applied to this compound, such as acylation, alkylation, or esterification, to introduce new functional groups.
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tert-Butyl 3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate
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(R)-2-(tert-Butoxycarbonyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
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2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid
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(S)-2-(tert-Butoxycarbonyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
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1-(tert-Butoxycarbonyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
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tert-Butyl 6-bromo-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indole-2-carboxylate
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1-Isobutyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
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2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
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6-Methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
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(S)-2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
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(S)-Methyl 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
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(R)-2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid