Chemistry Heterocyclic Building Blocks Pyridines 2,3,6-trichloropyridine
Nucleophilic substitution: The chlorine atoms in the molecule can be substituted by nucleophiles such as hydroxide ions, amines, or thiols, leading to the formation of various substituted pyridine derivatives.
Electrophilic aromatic substitution: The electron-deficient nature of the pyridine ring makes it susceptible to electrophilic aromatic substitution reactions, where electrophiles attack the aromatic ring. This can lead to the formation of various substituted products depending on the nature of the electrophile.
Metalation: 2,3,6-trichloropyridine can react with strong bases to form metal complexes through metalation reactions. This can be useful in synthesizing organometallic compounds or coordinating ligands for metal catalysts.
Reduction: The chlorine atoms in 2,3,6-trichloropyridine can be reduced to form the corresponding di- or mono-chloropyridines, or even completely reduced to form the corresponding piperidine derivative.
Oxidation: The pyridine ring can undergo oxidation reactions under appropriate conditions, leading to the formation of various oxidized products.
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2,3,6-Trichloro-5-(trifluoromethyl)pyridine
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2,3,5,6-Tetrachloro-4-(methylsulfonyl)pyridine
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2,3,6-Trichloro-4-(trifluoromethyl)pyridine