Chemistry Heterocyclic Building Blocks Pyridines 2,3-dibromopyridine
Ambeed provide 21 derivatives of 2,3-dibromopyridine.
These compounds have the same murcko framework: 2,3-dibromopyridineSubstitution reactions: The bromine atoms on the pyridine ring are susceptible to substitution reactions with various nucleophiles or other electrophiles. For instance, they can be substituted with other halogens, alkyl groups, or aryl groups.
Metalation reactions: The pyridine ring can undergo metalation reactions where a metal atom replaces one of the hydrogen atoms on the ring. This can lead to the formation of metal complexes which can have various applications in catalysis or coordination chemistry.
Reduction reactions: The bromine atoms in 2,3-dibromopyridine can be reduced to form dihalogenated pyridine derivatives or completely dehalogenated pyridine derivatives, depending on the reaction conditions and the reducing agents used.
Cross-coupling reactions: 2,3-dibromopyridine can undergo cross-coupling reactions with various coupling partners under appropriate reaction conditions. Palladium-catalyzed coupling reactions, such as Suzuki coupling or Heck coupling, are commonly employed in these reactions.
Nucleophilic aromatic substitution: The electron-deficient pyridine ring can undergo nucleophilic aromatic substitution reactions, where a nucleophile substitutes one of the bromine atoms on the ring. The nature of the nucleophile and reaction conditions can determine the regioselectivity of the substitution.
Functional group transformations: 2,3-dibromopyridine can undergo various functional group transformations, such as oxidation, reduction, or functional group interconversion, leading to the formation of diverse pyridine derivatives with different chemical properties.
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