Chemistry Heterocyclic Building Blocks Pyridines 2,3-difluoropyridine
Ambeed provide 13 derivatives of 2,3-difluoropyridine.
These compounds have the same murcko framework: 2,3-difluoropyridineElectrophilic Aromatic Substitution (EAS): 2,3-difluoropyridine can undergo EAS reactions where an electrophile substitutes one of the hydrogen atoms on the aromatic ring. This could lead to the formation of various substituted products depending on the nature of the electrophile and the reaction conditions.
Nucleophilic Aromatic Substitution (SNAr): Depending on the reaction conditions and the substituents present on the aromatic ring, 2,3-difluoropyridine might also undergo nucleophilic aromatic substitution reactions where a nucleophile substitutes one of the fluorine atoms on the pyridine ring.
Metalation: The pyridine ring can be metalated at the 2 or 3 position by treatment with strong bases, such as n-butyllithium or LDA (lithium diisopropylamide), leading to the formation of organometallic intermediates which can further react with various electrophiles.
Cross-Coupling Reactions: 2,3-difluoropyridine can participate in various transition metal-catalyzed cross-coupling reactions, such as Suzuki, Sonogashira, Heck, or Stille reactions, allowing the introduction of diverse substituents at the 2 and 3 positions.
Functional Group Transformations: The fluorine atoms on the pyridine ring can undergo various transformations, such as substitution reactions, reduction, or oxidation reactions, depending on the reagents and conditions employed.
Heterocycle Formation: Depending on the reaction conditions, 2,3-difluoropyridine can undergo cyclization reactions with appropriate reagents to form fused or spiro heterocyclic compounds.
Nitration, Halogenation, and Sulfonation: The electron-rich nature of the pyridine ring can make it susceptible to nitration, halogenation, and sulfonation reactions under appropriate conditions.
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2,3-Difluoro-4-(trifluoromethyl)pyridine