Chemistry Heterocyclic Building Blocks Pyridines 2,3-dihydro-[1,4]dioxino[2,3-b]pyridine
Ambeed provide 5 derivatives of 2,3-dihydro-[1,4]dioxino[2,3-b]pyridine.
These compounds have the same murcko framework: 2,3-dihydro-[1,4]dioxino[2,3-b]pyridine.
Aromatic Substitution: The pyridine ring in the structure can undergo typical electrophilic aromatic substitution reactions. For instance, it may react with electrophiles like acyl chlorides or nitration reagents.
Nucleophilic Addition: The dioxino ring, being an oxygen-containing heterocycle, can react with nucleophiles. For example, it may undergo nucleophilic addition reactions with strong nucleophiles like organometallic reagents.
Oxidation: The presence of heteroatoms (nitrogen and oxygen) in the molecule makes it susceptible to oxidation reactions. It could potentially be oxidized using common oxidizing agents like potassium permanganate, chromates, or peracids.
Reduction: The compound may undergo reduction reactions to convert functional groups. For instance, the pyridine ring could be reduced to a piperidine ring using a reducing agent like lithium aluminum hydride (LiAlH4).
Cyclization: The compound's structure could participate in intramolecular reactions, leading to the formation of various cyclic compounds.
Substitution Reactions: Depending on the substituents attached to the pyridine ring, it may undergo various substitution reactions like SN1 or SN2 reactions.
Acid-Base Reactions: The compound may participate in acid-base reactions, especially involving the basic nitrogen atom.
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(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-6-yl)methanol
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8-Bromo-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine
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7-Bromo-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine
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2,3-Dihydro-[1,4]dioxino[2,3-b]pyridine-7-carboxylic acid