Chemistry Heterocyclic Building Blocks Pyridines 2,3-dihydro-1H-pyrrolo[2,3-b]pyridine
Ambeed provide 10 derivatives of 2,3-dihydro-1H-pyrrolo[2,3-b]pyridine.
These compounds have the same murcko framework: 2,3-dihydro-1H-pyrrolo[2,3-b]pyridine.
Acylation and Alkylation: 2,3-dihydro-1H-pyrrolo[2,3-b]pyridine can undergo acylation and alkylation reactions, allowing the introduction of various substituents at the nitrogen or carbon atoms in the pyrrolopyridine ring system.
Nucleophilic Addition: The nitrogen atom in the pyrrolopyridine ring can undergo nucleophilic addition reactions, particularly if it's protonated to form a more reactive species. This can be useful in the synthesis of various derivatives.
Amination: Amination reactions can be used to introduce amino groups into the molecule. For example, you can react it with an amine source under appropriate conditions.
Oxidation: Depending on the reaction conditions and reagents, oxidation reactions can be used to convert the compound into various oxidized derivatives.
Reduction: Reduction reactions can be employed to reduce the compound to its corresponding saturated form.
Cyclization: Depending on the functional groups present, it might undergo intramolecular cyclization reactions to form other fused ring systems.
Cross-Coupling Reactions: 2,3-dihydro-1H-pyrrolo[2,3-b]pyridine can participate in cross-coupling reactions, such as Suzuki, Heck, or Stille reactions, to form biaryl or related compounds when appropriate coupling partners are used.
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tert-Butyl 5-bromo-3-methyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-1-carboxylate
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5-Iodo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine
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5-Bromo-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine
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4-Nitro-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine
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5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine hydrochloride
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5-Bromo-1-methyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine
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5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine
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6-Chloro-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine
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5-Chloro-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine