Chemistry Heterocyclic Building Blocks Pyridines 2,3-dihydro-1H-pyrrolo[3,2-c]pyridine
Ambeed provide 7 derivatives of 2,3-dihydro-1H-pyrrolo[3,2-c]pyridine.
These compounds have the same murcko framework: 2,3-dihydro-1H-pyrrolo[3,2-c]pyridine.
Aromatization: Under appropriate conditions, 2,3-dihydro-1H-pyrrolo[3,2-c]pyridine can undergo aromatization to form the aromatic compound, pyrrolo[3,2-c]pyridine. This can be achieved through oxidation or other methods that break the cyclic structure.
Substitution Reactions: Depending on the substituents on the pyrrolopyridine ring, it can undergo nucleophilic or electrophilic substitution reactions. For example, if there are halogen atoms or other leaving groups present, they can be substituted with nucleophiles or other groups.
Ring Opening Reactions: In the presence of suitable reagents, the ring can be opened to form open-chain compounds. This can involve cleavage of one of the bonds in the ring.
Functional Group Transformations: Various functional group transformations can be carried out on 2,3-dihydro-1H-pyrrolo[3,2-c]pyridine. For example, you can perform reduction reactions, oxidation reactions, or addition reactions depending on the desired product.
Cyclization Reactions: It's possible to use 2,3-dihydro-1H-pyrrolo[3,2-c]pyridine as a starting material for cyclization reactions to form other heterocyclic compounds or fused-ring systems.
N-Heterocyclic Carbene (NHC) Formation: The nitrogen atom in the pyrrolopyridine ring can be used to generate N-heterocyclic carbenes, which are important intermediates in various organometallic reactions.
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tert-Butyl 4-chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine-1-carboxylate
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2,3-Dihydro-1H-pyrrolo[3,2-c]pyridine hydrochloride
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6-Chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine
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tert-Butyl 6-chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine-1-carboxylate
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6-Bromo-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine hydrochloride
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6-Chloro-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine
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4-Chloro-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine