Chemistry Organic Building Blocks Bromides methyl 2-bromo-3-nitrobenzoate
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—NO2,—COOCH3).
Electrophilic Aromatic Substitution (EAS): Bromobenzene can react with electrophiles in substitution reactions, such as nitration, sulfonation, halogenation, and Friedel-Crafts acylation/alkylation.
Sulfonation: Nitrobenzene can be sulfonated to introduce a sulfonic acid group (-SO3H) onto the benzene ring. Sulfonation is carried out using concentrated sulfuric acid, which leads to the substitution of one of the hydrogen atoms on the ring.
Fischer Esterification: Methyl benzoate can be synthesized through Fischer esterification, where benzoic acid reacts with methanol in the presence of an acid catalyst, typically sulfuric acid. This reaction forms the ester bond and releases water as a byproduct.
Framework+−
By Key Group+−
By Parent Nucleus+−
By Functional Group+−
Halogen related+−
Formula Weight+−
click to sign in and save
Methyl 2,5,6-trichloropyrimidine-4-carboxylate
click to sign in and save
2,4,5-Trichloro-6-(trifluoromethyl)pyrimidine