Chemistry Heterocyclic Building Blocks Pyrimidines 2,4,6-trichloropyrimidine
Ambeed provide 14 derivatives of 2,4,6-trichloropyrimidine.
These compounds have the same murcko framework: 2,4,6-trichloropyrimidineNucleophilic Substitution Reactions: The chlorine atoms on the pyrimidine ring can be replaced by nucleophiles. For example, treatment with a nucleophile (such as amines or alkoxides) can lead to substitution reactions, forming substituted pyrimidine derivatives.
Cross-Coupling Reactions: 2,4,6-Trichloropyrimidine can participate in cross-coupling reactions, such as Suzuki coupling or Stille coupling, where it reacts with suitable partners to form biaryl or heteroaryl compounds.
Amination Reactions: The chlorine atoms can be replaced by amine groups through nucleophilic substitution reactions, resulting in substituted amino pyrimidines.
Alkylation Reactions: The compound can undergo alkylation reactions, where the chlorine atoms are replaced by alkyl groups, typically in the presence of strong bases or nucleophiles.
Reduction: The compound can be reduced to form the corresponding dihydro or tetrahydro derivatives, depending on the reaction conditions.
Metalation: The pyrimidine ring can be metalated, allowing for further reactions with electrophiles or nucleophiles.
Oxidation Reactions: Under certain conditions, 2,4,6-trichloropyrimidine may undergo oxidation, potentially leading to the formation of other functional groups.
Substitution with Grignard Reagents: Grignard reagents, which are strong nucleophiles, can react with 2,4,6-trichloropyrimidine to form substituted pyrimidines.
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1-(2,4,6-Trichloropyrimidin-5-yl)ethanone
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Ethyl 2-(2,4,6-trichloropyrimidin-5-yl)acetate
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2,4,6-Trichloropyrimidine-5-carboxylic acid
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(2,4,6-Trichloropyrimidin-5-yl)methanol