Chemistry Heterocyclic Building Blocks Pyridines 2,5-dibromopyridine
Ambeed provide 26 derivatives of 2,5-dibromopyridine.
These compounds have the same murcko framework: 2,5-dibromopyridineSubstitution Reactions: 2,5-dibromopyridine can undergo substitution reactions where one or both of the bromine atoms are replaced by other functional groups. This could involve reactions with nucleophiles (e.g., amines, thiols) or electrophiles (e.g., Friedel-Crafts acylation, Friedel-Crafts alkylation).
Metalation Reactions: The pyridine ring can be deprotonated by strong bases to form pyridine anions, which can then react with various electrophiles or undergo further transformations.
Cross-Coupling Reactions: 2,5-dibromopyridine can participate in cross-coupling reactions, such as Suzuki-Miyaura coupling or Stille coupling, where it reacts with another organic halide or organometallic reagent to form a biaryl or heteroaryl compound.
Oxidation Reactions: The pyridine ring can undergo oxidation reactions, leading to the formation of pyridine N-oxides or other oxidized derivatives.
Reduction Reactions: Reduction of the bromine atoms or the pyridine ring itself can occur, leading to the formation of dihydro derivatives or saturated heterocycles.
Functional Group Transformations: Various functional groups can be introduced or modified on the pyridine ring through different synthetic methodologies, such as halogenation, nitration, sulfonation, etc.
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3,6-Dibromopyridine-2-carboxylic acid