Chemistry Heterocyclic Building Blocks Pyridines 2,5-dichloropyridine
Ambeed provide 32 derivatives of 2,5-dichloropyridine.
These compounds have the same murcko framework: 2,5-dichloropyridineNucleophilic Substitution: The chlorine atoms in 2,5-dichloropyridine can be replaced by nucleophiles, such as amines or alkoxides, leading to the formation of substituted pyridines.
Reduction: 2,5-dichloropyridine can be reduced to 2,5-dichloropyridine or further reduced to the corresponding dihydropyridine derivative using reducing agents like hydrogen gas with a catalyst or complex metal hydrides.
Electrophilic Aromatic Substitution (EAS): The electron-rich pyridine ring can undergo EAS reactions, where electrophiles attack the aromatic ring. The chlorine atoms can act as directing groups, facilitating substitution at the ortho and para positions.
Metalation: The pyridine ring can undergo metalation reactions, where a metal reagent, such as an organolithium or Grignard reagent, substitutes one of the hydrogen atoms on the ring, forming a metal-pyridine complex.
Cross-Coupling Reactions: 2,5-dichloropyridine can participate in cross-coupling reactions, such as Suzuki-Miyaura, Stille, or Heck reactions, where it reacts with suitable partners under catalytic conditions to form biaryl or heteroaryl compounds.
Halogenation: The chlorine atoms in 2,5-dichloropyridine can undergo further halogenation reactions under appropriate conditions, leading to compounds with multiple halogen substituents.
Oxidation: The pyridine ring can be oxidized under certain conditions to form pyridine N-oxides or other oxidized derivatives.
Ring Closure Reactions: 2,5-dichloropyridine can participate in ring closure reactions to form various heterocyclic compounds, such as pyrimidines or pyrazines, through appropriate cyclization conditions.
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2,5-Dichloro-3-(trifluoromethyl)pyridine
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2,5-Dichloropyridine-3-sulfonyl chloride
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2,5-Dichloro-4-(trifluoromethyl)pyridine
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1-(3,6-Dichloropyridin-2-yl)ethan-1-one