Chemistry Heterocyclic Building Blocks Pyridines 2,6-bis(4,5-dihydrooxazol-2-yl)pyridine
Ambeed provide 12 derivatives of 2,6-bis(4,5-dihydrooxazol-2-yl)pyridine.
These compounds have the same murcko framework: 2,6-bis(4,5-dihydrooxazol-2-yl)pyridine.
Nucleophilic Substitution: The oxazole moieties in the compound can potentially undergo nucleophilic substitution reactions, where a nucleophile replaces another group or atom. The exact nature of the substitution will depend on the reaction conditions and the nature of the nucleophile.
Oxidation: The compound may be susceptible to oxidation reactions, depending on the specific functional groups present in the molecule. Oxidizing agents like peroxides, permanganates, or chromates could be used.
Metal-Catalyzed Reactions: The pyridine moiety can act as a ligand in metal-catalyzed reactions, allowing for various transformations such as cross-coupling reactions or oxidative addition reactions. The exact reaction will depend on the metal catalyst employed.
Reductive Processes: Compounds with oxazole moieties can be reduced using reducing agents like sodium borohydride or lithium aluminum hydride, leading to the formation of corresponding amines or alcohols, respectively.
Heterocyclic Chemistry: The presence of both oxazole and pyridine rings suggests the potential for various heterocyclic reactions. These may involve ring-opening, ring-closing, or annulation reactions.
N-alkylation or N-acylation: The nitrogen atoms in both the oxazole and pyridine rings can undergo alkylation or acylation reactions, typically in the presence of suitable reagents and catalysts.
Halogenation: The compound may undergo halogenation reactions when treated with halogenating agents like chlorine or bromine, depending on the reaction conditions and the reactivity of the compound.
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2,6-Bis((R)-4-methyl-4,5-dihydrooxazol-2-yl)pyridine
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2,6-Bis((S)-4-((S)-sec-butyl)-4,5-dihydrooxazol-2-yl)pyridine
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2,6-Bis((R)-4-ethyl-4,5-dihydrooxazol-2-yl)pyridine
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2,6-Bis((R)-4-isobutyl-4,5-dihydrooxazol-2-yl)pyridine
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2,6-Bis((S)-4-isobutyl-4,5-dihydrooxazol-2-yl)pyridine
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2,6-Bis((S)-4-methyl-4,5-dihydrooxazol-2-yl)pyridine
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2,6-Bis((R)-4-isopropyl-4,5-dihydrooxazol-2-yl)pyridine
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2,6-Bis((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)pyridine
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2,6-Bis((S)-4-(tert-butyl)-4,5-dihydrooxazol-2-yl)pyridine
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(4S,4'S)-2,2'-(4-Bromopyridine-2,6-diyl)bis(4-isopropyl-4,5-dihydrooxazole)
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2,6-Bis((R)-4-(tert-butyl)-4,5-dihydrooxazol-2-yl)pyridine