Chemistry Heterocyclic Building Blocks Pyridines 2,6-di(1H-pyrazol-1-yl)pyridine
Ambeed provide 5 derivatives of 2,6-di(1H-pyrazol-1-yl)pyridine.
These compounds have the same murcko framework: 2,6-di(1H-pyrazol-1-yl)pyridine.
Substitution Reactions: The pyridine ring in 2,6-di(1H-pyrazol-1-yl)pyridine can undergo electrophilic aromatic substitution reactions, such as nitration, halogenation, or Friedel-Crafts acylation/alkylation.
Metalation Reactions: The pyrazole rings can serve as coordinating ligands for various transition metals. You can perform metalation reactions to introduce metal atoms (e.g., palladium, copper, or nickel) into the structure. This can lead to the formation of organometallic complexes with potential catalytic properties.
Cross-Coupling Reactions: You can conduct cross-coupling reactions with 2,6-di(1H-pyrazol-1-yl)pyridine, such as Suzuki-Miyaura, Heck, or Sonogashira reactions, to form new carbon-carbon or carbon-heteroatom bonds. These reactions are commonly used in the synthesis of organic compounds.
Oxidation and Reduction Reactions: You can oxidize or reduce the compound at various positions to modify its chemical properties. For example, you can reduce the pyridine or pyrazole rings to the corresponding dihydro derivatives using reducing agents.
Grignard Reactions: You can use Grignard reagents to react with 2,6-di(1H-pyrazol-1-yl)pyridine, leading to the formation of various functional groups.
Condensation Reactions: It can participate in condensation reactions, such as acylation or alkylation reactions, to form new compounds by replacing a hydrogen atom with an acyl or alkyl group.
Complexation Reactions: The compound can form complexes with various metal ions, and these complexes may have interesting catalytic or coordination chemistry applications.
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2,6-Bis(4-methyl-1H-pyrazol-1-yl)pyridine
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2,6-Bis(3-methyl-1H-pyrazol-1-yl)pyridine
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1,1'-(Pyridine-2,6-diyl)bis(1H-pyrazole-3-carboxylic acid)
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2,6-Di(1H-pyrazol-1-yl)isonicotinic acid