Chemistry
Heterocyclic Building Blocks
Pyridines
2,6-dibromopyridin-4-amine
Nucleophilic Substitution: The amino group (-NH2) can act as a nucleophile, participating in substitution reactions with electrophiles. For instance, it can undergo nucleophilic aromatic substitution (S[sub]N[/sub]Ar) reactions.
Reductive Amination: The amino group (-NH2) can undergo reductive amination reactions with appropriate carbonyl compounds (such as aldehydes or ketones) in the presence of reducing agents to form secondary or tertiary amines.
Bromination: The bromine atoms on the pyridine ring can undergo substitution reactions. For instance, they can be replaced by other nucleophiles or functional groups under appropriate conditions.
Cross-Coupling Reactions: The amino group can participate in cross-coupling reactions, such as Suzuki coupling or Buchwald-Hartwig coupling, to form carbon-nitrogen bonds with various aryl or heteroaryl halides.
Arylation: The amino group can be arylated using appropriate aryl halides or arylboronic acids under palladium-catalyzed conditions to introduce aryl groups onto the amino group.
Redox Reactions: The bromine atoms can participate in redox reactions, either as oxidizing or reducing agents, depending on the reaction conditions and the presence of other reactants.
Metal Complexation: The amino and pyridine moieties can coordinate with transition metal ions to form metal complexes, which can further participate in various catalytic reactions.
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