Chemistry Heterocyclic Building Blocks Pyridines 2,6-dibromopyridine
Substitution Reactions: The bromine atoms can be replaced by other functional groups or nucleophiles through substitution reactions. For example, nucleophilic substitution reactions with amines or thiols can occur to form substituted pyridines.
Metalation Reactions: 2,6-dibromopyridine can undergo metalation reactions with strong bases such as butyllithium or Grignard reagents, leading to the formation of organometallic intermediates which can subsequently react in various ways.
Cross-Coupling Reactions: 2,6-dibromopyridine can participate in cross-coupling reactions, such as Suzuki coupling or Stille coupling, where it can react with appropriate coupling partners to form biaryl or heteroaryl compounds.
Oxidation Reactions: The bromine atoms can be oxidized to other functional groups. For instance, oxidation of the bromine atoms to carbonyl groups can occur using oxidizing agents like chromates or permanganates.
Reduction Reactions: The bromine atoms can be reduced to other functional groups. For example, reduction with metal hydrides such as lithium aluminum hydride (LiAlH4) can lead to the formation of dihydro compounds.
Cyclization Reactions: Under certain conditions, 2,6-dibromopyridine can undergo intramolecular cyclization reactions, forming cyclic compounds with the pyridine ring.
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2,6-Dibromo-4-(trifluoromethyl)pyridine