Chemistry Heterocyclic Building Blocks Pyridines 2,6-dichloro-3-fluoropyridine
Ambeed provide 10 derivatives of 2,6-dichloro-3-fluoropyridine.
These compounds have the same murcko framework: 2,6-dichloro-3-fluoropyridineNucleophilic substitution reactions: The halogen atoms (chlorine and fluorine) can be substituted by nucleophiles such as amines, alcohols, or thiols.
Electrophilic aromatic substitution reactions: The electron-rich pyridine ring can undergo substitution reactions with electrophiles, such as nitration, halogenation, sulfonation, or Friedel-Crafts acylation/alkylation.
Cross-coupling reactions: The compound can participate in various cross-coupling reactions, such as Suzuki-Miyaura, Stille, or Heck reactions, to form carbon-carbon bonds.
Reduction reactions: The halogen substituents may undergo reduction to yield corresponding alkyl or aryl groups.
Oxidation reactions: The compound can be oxidized to form various functional groups, such as ketones, aldehydes, or carboxylic acids.
Metal complexation reactions: The compound may form complexes with transition metals, altering its reactivity and properties.
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2,6-Dichloro-5-fluoropyridin-3-amine hydrochloride
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Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate
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2,6-Dichloro-5-fluoro-4-methylnicotinic acid
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Ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate