Chemistry Heterocyclic Building Blocks Pyridines 2,6-dichloro-3-methylpyridine
Ambeed provide 5 derivatives of 2,6-dichloro-3-methylpyridine.
These compounds have the same murcko framework: 2,6-dichloro-3-methylpyridineSubstitution Reactions: Being a substituted pyridine, it can undergo substitution reactions at the 2- and 6-positions due to the presence of the electron-rich aromatic system. This includes nucleophilic aromatic substitution (SNAr) reactions where a nucleophile replaces a leaving group on the pyridine ring.
Metalation Reactions: The compound can undergo metalation reactions where a metal species (e.g., lithium, magnesium) replaces a hydrogen atom on the pyridine ring. This can be useful for further functionalization or synthesis of more complex molecules.
Oxidation Reactions: 2,6-dichloro-3-methylpyridine can undergo oxidation reactions, especially at the methyl group, leading to the formation of corresponding alcohols, ketones, or carboxylic acids.
Reduction Reactions: Similarly, reduction reactions can occur, converting the pyridine ring or the substituents to their reduced forms.
Nucleophilic Addition: It can undergo nucleophilic addition reactions, especially at the pyridine ring, resulting in the addition of a nucleophile to the ring.
Halogenation Reactions: The compound being already chlorinated may undergo further halogenation reactions under appropriate conditions, where other halogens replace the chlorine atoms.
Condensation Reactions: It can undergo condensation reactions with appropriate reagents to form heterocyclic compounds or other organic molecules.
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1-(2,6-Dichloro-3-methylpyridin-4-yl)ethanone
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2,6-Dichloro-3-methylisonicotinic acid