Chemistry Heterocyclic Building Blocks Pyridines 2,6-dichloro-3-nitropyridine
Ambeed provide 6 derivatives of 2,6-dichloro-3-nitropyridine.
These compounds have the same murcko framework: 2,6-dichloro-3-nitropyridineNucleophilic substitution: The chloro substituents can undergo nucleophilic substitution reactions. For instance, they can be replaced by nucleophiles such as amines or thiols to form corresponding amine or thiol derivatives.
Reduction of the nitro group: The nitro group (-NO2) is reducible to amino group (-NH2) under suitable conditions. This reduction can be achieved using various reducing agents such as iron with hydrochloric acid (Fe/HCl), tin and hydrochloric acid (Sn/HCl), or catalytic hydrogenation.
Electrophilic aromatic substitution: The electron-deficient nature of the nitro group can make the pyridine ring susceptible to electrophilic aromatic substitution reactions. For example, it can undergo reactions with strong electrophiles to introduce substituents at the aromatic ring.
Metalation reactions: The compound may undergo metalation reactions where a metal inserts into a carbon-halogen bond, forming a metal-organic compound which can further react with various electrophiles.
Cross-coupling reactions: The compound can participate in cross-coupling reactions, such as Suzuki, Stille, or Heck reactions, which involve the coupling of two different organic fragments.
Oxidation reactions: The compound can undergo oxidation reactions, depending on the conditions and the nature of oxidizing agents present.
Substitution reactions: Depending on the reaction conditions, other substitution reactions at different positions on the pyridine ring may occur.
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2,6-Dichloro-4-methoxy-3-nitropyridine