Chemistry Heterocyclic Building Blocks Pyridines 2,6-dichloro-4-methylpyridine
Ambeed provide 5 derivatives of 2,6-dichloro-4-methylpyridine.
These compounds have the same murcko framework: 2,6-dichloro-4-methylpyridineSubstitution Reactions: The chlorine atoms in the molecule can be substituted by other nucleophiles. For instance, nucleophilic substitution reactions can occur with various nucleophiles such as hydroxide ions (OH⁻), amines, or thiolates, leading to the formation of substituted products.
Metalation: The pyridine ring can act as a ligand and undergo metalation reactions with certain metal reagents, forming metal complexes. This can modify the reactivity and properties of the molecule.
Oxidation: The methyl group in the molecule can undergo oxidation under appropriate conditions, yielding carboxylic acid or ketone derivatives.
Reduction: Conversely, the chlorine atoms or the pyridine ring can be reduced under suitable conditions, leading to the formation of corresponding chloro or dihydropyridine derivatives, respectively.
Nucleophilic Addition: The pyridine ring can undergo nucleophilic addition reactions under specific conditions, leading to the formation of ring-substituted products.
Acylation: The pyridine ring can undergo acylation reactions, where acyl groups are introduced onto the nitrogen atom or at other positions on the ring.
Alkylation: Alkylation reactions can occur, introducing alkyl groups onto the pyridine ring through nucleophilic substitution or other mechanisms.
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Ethyl 2,6-dichloro-4-methylnicotinate