Chemistry Heterocyclic Building Blocks Pyridines 2,6-dichloropyridine
Ambeed provide 49 derivatives of 2,6-dichloropyridine.
These compounds have the same murcko framework: 2,6-dichloropyridineNucleophilic Substitution: The chlorine atoms on the pyridine ring can be replaced by nucleophiles such as hydroxide ions, amines, or thiolates, resulting in the formation of substituted pyridines.
Metalation: 2,6-dichloropyridine can undergo metalation reactions, where a metal atom replaces one of the chlorine atoms. This reaction is often performed using strong bases and can lead to the formation of organometallic complexes.
Reductive Dehalogenation: Under certain conditions, 2,6-dichloropyridine can undergo reductive dehalogenation reactions, leading to the removal of chlorine atoms and the formation of dihydropyridine derivatives.
Cross-Coupling Reactions: 2,6-dichloropyridine can participate in cross-coupling reactions, such as Suzuki-Miyaura or Heck reactions, where it reacts with suitable coupling partners in the presence of a catalyst to form biaryl or alkylated pyridine derivatives.
Aromatic Substitution: The electron-rich nature of the pyridine ring can undergo electrophilic aromatic substitution reactions, where electron-deficient species replace one of the hydrogen atoms on the ring. This can lead to the introduction of various functional groups onto the pyridine ring.
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2,6-Dichloro-N-methylpyridin-4-amine
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tert-Butyl 2,6-dichloroisonicotinate
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2,6-Dichloropyridine-4-sulfonyl chloride
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2,6-Dichloro-3-hydroxyisonicotinaldehyde
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Ethyl 3-(2,6-dichloropyridin-3-yl)-3-oxopropanoate
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2,6-Dichloro-3-hydroxyisonicotinic acid
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tert-Butyl (2,6-dichloropyridin-4-yl)carbamate
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2,6-Dichloro-N-methoxy-N-methylisonicotinamide
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2,6-Dichloro-3-(trimethylstannyl)pyridine
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2,6-Dichloro-5-methoxynicotinonitrile
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(2,6-Dichloropyridin-3-yl)methanamine hydrochloride
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2,6-Dichloro-N,N-dimethylpyridin-4-amine
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tert-Butyl ((2,6-dichloropyridin-3-yl)methyl)carbamate
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Methyl 2-(2,6-dichloropyridin-4-yl)acetate