Chemistry Heterocyclic Building Blocks Pyridines 2,6-difluoropyridine
Ambeed provide 29 derivatives of 2,6-difluoropyridine.
These compounds have the same murcko framework: 2,6-difluoropyridineNucleophilic Substitution: The fluorine atoms can be replaced by nucleophiles in a substitution reaction. For example, nucleophilic aromatic substitution reactions could occur.
Electrophilic Aromatic Substitution: The pyridine ring can undergo electrophilic aromatic substitution reactions, where an electrophile attacks the aromatic ring leading to substitution. The fluorine atoms can influence the reactivity and regioselectivity of such reactions.
Metalation: The pyridine ring can undergo metalation reactions where a metal species replaces one of the hydrogen atoms on the ring, forming a metal complex.
Redox Reactions: The presence of the fluorine atoms can influence the redox properties of the molecule, allowing it to participate in various redox reactions.
Functional Group Transformations: The fluorine atoms and the pyridine ring can undergo various functional group transformations such as oxidation, reduction, and addition reactions.
Cross-Coupling Reactions: 2,6-difluoropyridine can participate in cross-coupling reactions, where it reacts with another organic molecule in the presence of a catalyst to form a new carbon-carbon or carbon-heteroatom bond.
Halogenation: The fluorine atoms can participate in halogenation reactions under appropriate conditions.
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