Chemistry Heterocyclic Building Blocks Pyridines 2,6-dimethoxypyridine
Ambeed provide 11 derivatives of 2,6-dimethoxypyridine.
These compounds have the same murcko framework: 2,6-dimethoxypyridineNucleophilic Substitution: The methoxy groups can undergo nucleophilic substitution reactions with appropriate electrophiles, replacing one or both methoxy groups with another functional group.
Acylation and alkylation: 2,6-DMP can undergo acylation or alkylation reactions at the nitrogen atom or at the positions adjacent to the methoxy groups.
Oxidation and Reduction: The aromatic ring can undergo oxidation reactions, potentially leading to the formation of aromatic aldehydes, ketones, or carboxylic acids. Conversely, reduction reactions could lead to the formation of partially or fully saturated derivatives.
Metal Complexation: The nitrogen atom can coordinate with transition metals to form metal complexes, enabling various catalytic reactions.
Heterocyclic Synthesis: 2,6-DMP can participate in heterocyclic synthesis, serving as a precursor or reacting partner in the formation of other heterocyclic compounds.
Protonation: The nitrogen atom can be protonated under acidic conditions, altering its reactivity and facilitating certain types of reactions.
Cross-coupling Reactions: 2,6-DMP can participate in cross-coupling reactions, such as Suzuki, Heck, or Stille coupling, enabling the formation of biaryl compounds.
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Potassium 2,6-dimethoxy-3-pyridinetrifluoroborate