Chemistry Heterocyclic Building Blocks Pyrazoles 2-(1H-pyrazol-1-yl)pyridine
Ambeed provide 16 derivatives of 2-(1H-pyrazol-1-yl)pyridine.
These compounds have the same murcko framework: 2-(1H-pyrazol-1-yl)pyridine.
Nucleophilic Substitution: The pyrazole nitrogen and pyridine nitrogen can act as nucleophilic sites, making it susceptible to substitution reactions with electrophiles. For example, it can react with alkyl halides to form N-alkylated or N-aryl pyrazole derivatives.
Acylation: 2-(1H-pyrazol-1-yl)pyridine can react with acyl chlorides or anhydrides to form amides. This reaction can be catalyzed by a base such as pyridine.
Metalation: It can undergo metalation reactions with strong bases, forming metal complexes. For example, treating it with strong bases like butyllithium can result in the deprotonation of the pyridine or pyrazole ring, leading to the formation of organometallic compounds.
Reduction: 2-(1H-pyrazol-1-yl)pyridine can be reduced using various reducing agents to obtain the corresponding dihydropyrazole or pyridine derivatives.
Oxidation: It can be oxidized to generate various products, depending on the oxidizing conditions used. Oxidation typically involves the formation of N-oxides, among other products.
Cyclization Reactions: Depending on the reaction conditions and reagents, it can undergo cyclization reactions to form complex heterocyclic compounds.
Functional Group Transformations: Various functional group transformations can be carried out on 2-(1H-pyrazol-1-yl)pyridine, including halogenation, alkylation, arylation, and more.
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5-Amino-1-(pyridin-2-yl)-1H-pyrazole-4-carbonitrile
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Ethyl 1-(6-bromopyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxylate
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5-Bromo-2-(3,5-dimethyl-1H-pyrazol-1-yl)pyridine
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Ethyl 5-amino-1-(pyridin-2-yl)-1H-pyrazole-4-carboxylate
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Methyl 6-(1H-pyrazol-1-yl)nicotinate
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1-(3-Chloropyridin-2-yl)-3-(trifluoromethyl)-1h-pyrazole-5-carboxylic acid
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3-Bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid
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Ethyl 1-(3-chloropyridin-2-yl)-3-(hydroxymethyl)-1H-pyrazole-5-carboxylate
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5-(Propan-2-yl)-1-(pyridin-2-yl)-1H-pyrazole-3-carboxylic acid
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4-(tert-Butyl)-2-(1H-pyrazol-1-yl)pyridine
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1-(Pyridin-2-yl)-1H-pyrazole-3-carboxylic acid
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5-Chloro-1-(pyridin-2-yl)-1H-pyrazole-4-carbonitrile