2-(1H-pyrazol-1-yl)pyrimidine-Pyrazoles| Ambeed

Chemistry Heterocyclic Building Blocks Pyrazoles 2-(1H-pyrazol-1-yl)pyrimidine

2-(1H-pyrazol-1-yl)pyrimidine

Ambeed provide 6 derivatives of 2-(1H-pyrazol-1-yl)pyrimidine.

These compounds have the same murcko framework: 2-(1H-pyrazol-1-yl)pyrimidine.

Substitution Reactions: The pyrimidine ring in 2-(1H-pyrazol-1-yl)pyrimidine can undergo nucleophilic substitution reactions, particularly at positions where electron-donating or electron-withdrawing groups are present. For example, you can perform nucleophilic substitution reactions with alkyl halides, resulting in the substitution of a halogen atom with the pyrimidine ring.
Metalation Reactions: You can use strong bases to deprotonate the pyrazole nitrogen, creating a pyrazolide anion, which can then react with various electrophiles in metalation reactions. For instance, it can react with alkyl halides to form N-alkylpyrazoles.
Cross-Coupling Reactions: 2-(1H-pyrazol-1-yl)pyrimidine can participate in cross-coupling reactions, such as Suzuki-Miyaura or Heck reactions, to form biaryl or alkyl-aryl compounds when used in combination with suitable coupling partners.
Oxidation Reactions: The pyrazole and pyrimidine rings can be oxidized under certain conditions, leading to the formation of corresponding oxides or other oxidized derivatives.
Reduction Reactions: The compound can also undergo reduction reactions, particularly at the pyrimidine ring, to yield reduced products.
Functional Group Transformations: Depending on the functional groups present in the molecule, you can perform various transformations, including acylation, alkylation, and esterification reactions, to modify the compound further.
Cyclization Reactions: Depending on the reaction conditions and reagents used, it may be possible to induce intramolecular cyclization reactions within the molecule, leading to the formation of different cyclic compounds.