Chemistry Heterocyclic Building Blocks Pyridines 2-(2,2,2-trifluoroethoxy)pyridine
Ambeed provide 8 derivatives of 2-(2,2,2-trifluoroethoxy)pyridine.
These compounds have the same murcko framework: 2-(2,2,2-trifluoroethoxy)pyridineSubstitution Reactions: The trifluoroethoxy group can undergo substitution reactions with various nucleophiles or electrophiles, leading to the formation of different derivatives.
Aromatic Substitution: The pyridine ring can undergo electrophilic aromatic substitution reactions, such as nitration, halogenation, sulfonation, etc., depending on the conditions and reagents used.
Reductive Reactions: The compound might undergo reduction reactions, especially if there are suitable functional groups present that can be reduced under specific conditions.
Oxidative Reactions: Under appropriate conditions, oxidative reactions might occur, leading to the formation of oxidized products.
Cross-Coupling Reactions: The compound can participate in cross-coupling reactions, such as Suzuki coupling, Heck reaction, etc., with suitable partner molecules.
Heterocyclic Chemistry: The presence of the pyridine ring makes it susceptible to various heterocyclic chemistry reactions, including ring-closure reactions and functional group transformations.
Basic Reactions: The pyridine nitrogen can undergo basic reactions, such as protonation or deprotonation, depending on the reaction conditions and the nature of the reacting species.
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6-(2,2,2-Trifluoroethoxy)pyridin-3-amine
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6-(2,2,2-Trifluoroethoxy)picolinic acid
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4-Bromo-2-(2,2,2-trifluoroethoxy)pyridine
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Methyl 6-(2,2,2-trifluoroethoxy)nicotinate
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(2-(2,2,2-Trifluoroethoxy)pyridin-3-yl)boronic acid