Chemistry Heterocyclic Building Blocks Pyrimidines thieno[2,3-d]pyrimidine
Nucleophilic Substitution: Thieno[2,3-d]pyrimidine contains nitrogen and sulfur atoms, making it susceptible to nucleophilic substitution reactions. Nucleophiles can displace halogens or other leaving groups attached to the ring.
Arylation: Thieno[2,3-d]pyrimidine can undergo palladium-catalyzed cross-coupling reactions with aryl halides or boronic acids to introduce aryl groups onto the heterocyclic ring.
Halogenation: Thieno[2,3-d]pyrimidine can be halogenated at various positions using halogenating agents like chlorine or bromine.
Alkylation: The nitrogen atoms in the thieno[2,3-d]pyrimidine ring can be alkylated using alkyl halides or other alkylating agents.
Sulfonation: The sulfur atom in the thieno[2,3-d]pyrimidine can be sulfonated using reagents like chlorosulfonic acid to introduce a sulfonyl group.
Reductive Reactions: Thieno[2,3-d]pyrimidine can undergo various reductive transformations using reducing agents like sodium borohydride or hydrogen gas in the presence of a catalyst.
Oxidation Reactions: Thieno[2,3-d]pyrimidine can be oxidized with oxidizing agents to introduce oxygen-containing functional groups.
Ring Opening Reactions: Thieno[2,3-d]pyrimidine can undergo ring-opening reactions, depending on the reaction conditions and reagents used.
Cyclization Reactions: Thieno[2,3-d]pyrimidine can participate in cyclization reactions to form other heterocyclic compounds.
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(R)-2-(2,6-Dichlorophenyl)pyrrolidine hydrochloride
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(R)-2-(2-Chlorophenyl)pyrrolidine hydrochloride
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(R)-2-(2-Chloro-5-fluorophenyl)pyrrolidine hydrochloride
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(R)-2-(2-Chloro-3-methylphenyl)pyrrolidine hydrochloride
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2-(2,5-Dichlorophenyl)pyrrolidine hydrochloride
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(R)-2-(2-Chloro-6-fluorophenyl)pyrrolidine hydrochloride
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(R)-2-(2,5-Dichlorophenyl)pyrrolidine hydrochloride
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(R)-2-(2-Chloro-4-methylphenyl)pyrrolidine hydrochloride
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(R)-2-(2-chloro-5-fluorophenyl)pyrrolidine
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(R)-2-(2,3-Dichlorophenyl)pyrrolidine hydrochloride
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(R)-2-(2-Chloro-4-fluorophenyl)pyrrolidine hydrochloride
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2-(2,4-Dichlorophenyl)pyrrolidine hydrochloride