Chemistry Heterocyclic Building Blocks Pyridines 2-(6-cyclopropylpyridin-2-yl)-4,5-dihydrooxazole
Ambeed provide 10 derivatives of 2-(6-cyclopropylpyridin-2-yl)-4,5-dihydrooxazole.
These compounds have the same murcko framework: 2-(6-cyclopropylpyridin-2-yl)-4,5-dihydrooxazole.
Substitution Reactions: Depending on the functional groups present, the oxazole ring or the pyridine ring can undergo substitution reactions. For example, you can perform nucleophilic substitution reactions at the oxazole or pyridine ring by reacting it with suitable nucleophiles.
Acylation/Alkylation: You can perform acylation or alkylation reactions with the oxygen atom in the oxazole ring or with the nitrogen atom in the pyridine ring. This can be achieved by using acylating agents or alkylating agents.
Reduction: The dihydrooxazole ring can be reduced to a saturated oxazole ring under appropriate conditions, typically by using reducing agents like sodium borohydride or catalytic hydrogenation.
Oxidation: Oxidation reactions can be employed to convert the dihydrooxazole ring to an oxazole ring, typically using oxidizing agents like potassium permanganate or peracids.
Condensation Reactions: This compound may undergo condensation reactions with other molecules containing suitable functional groups, leading to the formation of more complex compounds.
Cycloaddition Reactions: Depending on the reactants and conditions, cycloaddition reactions such as Diels-Alder reactions or 1,3-dipolar cycloadditions can be performed with this compound.
Metal-Catalyzed Reactions: Transition metal-catalyzed reactions can be used to functionalize this molecule at specific sites, such as C-C or C-N bond formations.
Rearrangement Reactions: Depending on the reaction conditions and the substituents present, rearrangement reactions such as ring-opening reactions or ring-closure reactions can occur.
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(R)-4-(tert-Butyl)-2-(6-cyclopropylpyridin-2-yl)-4,5-dihydrooxazole
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(S)-4-(tert-Butyl)-2-(6-cyclopropylpyridin-2-yl)-4,5-dihydrooxazole
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(R)-2-(6-Cyclopropylpyridin-2-yl)-4-ethyl-4,5-dihydrooxazole
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(S)-2-(6-Cyclopropylpyridin-2-yl)-4-isopropyl-4,5-dihydrooxazole
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(S)-4-((S)-sec-Butyl)-2-(6-cyclopropylpyridin-2-yl)-4,5-dihydrooxazole
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(S)-2-(6-Cyclopropylpyridin-2-yl)-4-ethyl-4,5-dihydrooxazole
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(S)-2-(6-Cyclopropylpyridin-2-yl)-4-methyl-4,5-dihydrooxazole
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(R)-2-(6-Cyclopropylpyridin-2-yl)-4-methyl-4,5-dihydrooxazole
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(R)-2-(6-Cyclopropylpyridin-2-yl)-4-isopropyl-4,5-dihydrooxazole
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(R)-2-(6-Cyclopropylpyridin-2-yl)-4-isobutyl-4,5-dihydrooxazole