Chemistry Heterocyclic Building Blocks Pyridines 2-(chloromethyl)-3-methylpyridine
Nucleophilic substitution: The chlorine atom can be replaced by a nucleophile, such as a hydroxide ion or an amine, resulting in the formation of a new compound with a substituted functional group.
Grignard reaction: The compound can react with a Grignard reagent (RMgX), where the Grignard reagent acts as a nucleophile attacking the carbon atom attached to the chlorine, leading to the formation of a new carbon-carbon bond.
Reduction: The compound can be reduced to yield a product where the chlorine atom is replaced with a hydrogen atom, typically using reducing agents like lithium aluminum hydride (LiAlH4) or hydrogen gas in the presence of a catalyst.
Alkylation: The compound can undergo alkylation reactions, where the chlorine atom is replaced with an alkyl group, either through SN2 substitution or using alkylating agents such as alkyl halides.
Acylation: The compound can react with acylating agents, such as acyl chlorides or acid anhydrides, leading to the introduction of an acyl group onto the nitrogen atom of the pyridine ring.
Oxidation: The compound can be oxidized under appropriate conditions to form compounds containing more oxidized functional groups.
Metalation: The compound may undergo metalation reactions, where a metal atom is introduced onto the pyridine ring, typically through the use of strong bases or metalating agents.
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2-(Chloromethyl)-3,5-dimethyl-4-nitropyridine
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2-(Chloromethyl)-3,5-dimethylpyridine hydrochloride
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2-(Chloromethyl)-3-methylpyridine hydrochloride
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4-Chloro-2-(chloromethyl)-3-methylpyridine hydrochloride
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2-(Chloromethyl)-3,5-dimethylpyridin-4-ol
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2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine
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2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride
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2-(Chloromethyl)-4-methoxy-3-methylpyridine hydrochloride
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3-((2-(Chloromethyl)-3-methylpyridin-4-yl)oxy)propan-1-ol