Chemistry Heterocyclic Building Blocks Pyridines 2-(chloromethyl)pyridine 1-oxide
Ambeed provide 4 derivatives of 2-(chloromethyl)pyridine 1-oxide.
These compounds have the same murcko framework: 2-(chloromethyl)pyridine 1-oxideNucleophilic Substitution: The chlorine atom can be replaced by a nucleophile, such as a hydroxide ion or an amine, leading to the formation of corresponding alcohol or amine derivatives.
Oxidation: The nitrogen atom in the pyridine ring can be further oxidized under certain conditions, leading to the formation of pyridine N-oxide derivatives.
Reduction: The pyridine N-oxide functionality can be reduced back to the corresponding pyridine derivative, typically by using reducing agents like sodium borohydride or hydrogen gas in the presence of a catalyst.
Metalation: The pyridine N-oxide can coordinate with transition metals, facilitating various metal-catalyzed reactions such as cross-coupling reactions or cyclization reactions.
Alkylation or Acylation: The nitrogen atom in the pyridine ring can undergo alkylation or acylation reactions, leading to the introduction of alkyl or acyl groups at the nitrogen position.
Ring-closure Reactions: The pyridine N-oxide can participate in ring-closure reactions under specific conditions, leading to the formation of fused or spirocyclic ring systems.
N-oxide Elimination: The N-oxide functionality can undergo elimination reactions under certain conditions, resulting in the regeneration of the parent pyridine.
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2-(Chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine 1-oxide hydrochloride
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2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine 1-oxide
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2-(Chloromethyl)-3,4-dimethoxypyridine 1-oxide