Chemistry Heterocyclic Building Blocks Pyridines 2-(difluoromethyl)pyridine
Ambeed provide 21 derivatives of 2-(difluoromethyl)pyridine.
These compounds have the same murcko framework: 2-(difluoromethyl)pyridineNucleophilic substitution reactions: The fluorine atoms in the difluoromethyl group can be substituted by nucleophiles, leading to the formation of different products.
Electrophilic aromatic substitution reactions: The pyridine ring can undergo electrophilic aromatic substitution reactions, where an electrophile substitutes a hydrogen atom on the ring.
Metalation reactions: The pyridine ring can be metalated at various positions, especially at the ortho and meta positions relative to the difluoromethyl group.
Oxidation reactions: The compound can undergo oxidation reactions to form various oxidized products.
Reduction reactions: Reduction of the difluoromethyl group or the pyridine ring can lead to the formation of different reduced products.
Functional group transformations: Various functional groups can be introduced or modified on the pyridine ring or the difluoromethyl group through appropriate reactions.
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2-(Difluoromethyl)pyridine-3-carboxamide
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Ethyl 2-(difluoromethyl)nicotinate
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6-(Difluoromethyl)-3-pyridinecarboxylic acid
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1-(2-(Difluoromethyl)pyridin-4-yl)ethanone
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2-(Difluoromethyl)-4-methyl-5-nitropyridine
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2-(Difluoromethyl)-3-fluoropyridin-4-amine hydrochloride
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2-(Difluoromethyl)-5-methoxynicotinic acid
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Methyl 2-(difluoromethyl)-6-methoxyisonicotinate
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(2-(Difluoromethyl)pyridin-4-yl)methanol
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2-(Difluoromethyl)pyridin-4-amine hydrochloride
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2-(Difluoromethyl)pyridine-3-carboxylic acid
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tert-Butyl ((2-(difluoromethyl)pyridin-4-yl)methyl)carbamate