Chemistry Heterocyclic Building Blocks Pyridines 2-(methylsulfonyl)pyridine
Ambeed provide 11 derivatives of 2-(methylsulfonyl)pyridine.
These compounds have the same murcko framework: 2-(methylsulfonyl)pyridineSubstitution Reactions: The methylsulfonyl group can undergo substitution reactions at the sulfur or at the carbon attached to the pyridine ring. These reactions can be nucleophilic substitutions, electrophilic substitutions, or radical substitutions.
Metalation Reactions: The pyridine ring can undergo metalation reactions, where a metal such as lithium or magnesium inserts into the C-H bond of the ring. This can lead to further functionalization reactions.
Oxidation Reactions: The sulfur atom in the methylsulfonyl group can be oxidized to sulfoxide or sulfone derivatives under appropriate conditions.
Reduction Reactions: The sulfonyl group can be reduced to sulfide or further to thiol derivatives.
Nucleophilic Addition Reactions: The pyridine ring can undergo addition reactions with various nucleophiles, particularly at positions that are not hindered by the methylsulfonyl group.
Cyclization Reactions: Depending on the conditions and the nature of the reactants, cyclization reactions involving the pyridine ring and the sulfonyl group can occur, leading to the formation of heterocyclic compounds.
Functional Group Interconversion Reactions: The methylsulfonyl group can undergo various functional group interconversions, such as conversion to methylthio, methylsulfinyl, or methylsulfonyl chloride derivatives.
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2-(Methylsulfonyl)isonicotinaldehyde
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4,6-Dimethyl-2-(methylsulfonyl)nicotinonitrile
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(6-(Methylsulfonyl)pyridin-3-yl)boronic acid
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2-(Methylsulfonyl)-4-pyridinecarboxylic Acid
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2-Methyl-6-(methylsulfonyl)pyridin-3-amine