Chemistry Heterocyclic Building Blocks Pyridines 2-(methylthio)pyridine
Ambeed provide 5 derivatives of 2-(methylthio)pyridine.
These compounds have the same murcko framework: 2-(methylthio)pyridineElectrophilic substitution: Similar to other aromatic compounds, 2-(methylthio)pyridine can undergo electrophilic substitution reactions where an electrophile substitutes for a hydrogen atom on the aromatic ring.
Nucleophilic substitution: The methylthio group can undergo nucleophilic substitution reactions where the sulfur atom acts as a nucleophile, replacing a leaving group in a suitable reaction.
Oxidation reactions: The sulfur atom in the methylthio group can be oxidized under appropriate conditions, leading to various oxidation products.
Metalation reactions: The pyridine ring can be metalated at the 2-position, where a metal atom replaces a hydrogen atom. This metalation can then lead to further reactions with electrophiles or nucleophiles.
Reduction reactions: The pyridine ring or the methylthio group can be reduced under appropriate conditions, yielding different products.
Substitution reactions: The methylthio group can undergo substitution reactions where it is replaced by other functional groups or moieties.
Functional group transformations: Various functional groups can be introduced or modified on the pyridine ring or the methylthio group through suitable chemical reactions.
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3-Bromo-2-(methylthio)-5-(trifluoromethyl)pyridine