Chemistry Heterocyclic Building Blocks Pyridines 2-(phenoxymethyl)pyridine
Ambeed provide 5 derivatives of 2-(phenoxymethyl)pyridine.
These compounds have the same murcko framework: 2-(phenoxymethyl)pyridine.
Acylation: 2-(phenoxymethyl)pyridine can undergo acylation reactions, where an acyl group (RCO-) is introduced. This can be achieved by treating it with acyl chlorides or anhydrides in the presence of a base or catalyst.
Alkylation: The pyridine ring in 2-(phenoxymethyl)pyridine can be alkylated using alkyl halides or alkyl sulfonates in the presence of a base, leading to the introduction of an alkyl group.
Amination: Amination reactions can be carried out to introduce amino groups into the molecule. This can be done by using ammonia or primary or secondary amines in the presence of suitable reagents or catalysts.
Oxidation: The phenoxymethyl group can be oxidized to form various functional groups, such as aldehydes or carboxylic acids , using oxidizing agents like potassium permanganate or chromium(VI) reagents.
Reduction: Reduction of the pyridine ring can be achieved using reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4), leading to the formation of piperidine derivatives.
Substitution: The pyridine ring can undergo nucleophilic substitution reactions, where various substituents can be introduced by reacting with appropriate nucleophiles in the presence of a suitable catalyst.
Grignard Reactions: It can react with Grignard reagents, leading to the formation of more complex organic compounds.
Heterocyclization: Depending on the reaction conditions, 2-(phenoxymethyl)pyridine can undergo intramolecular cyclization reactions to form various heterocyclic compounds.
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2-((2-Chloro-4-nitrophenoxy)methyl)pyridine
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(4-(Pyridin-2-ylmethoxy)phenyl)boronic acid